The planned May 5, 2018 rematch between Canelo Álvarez and Gennady Golovkin collapsed after Álvarez tested positive for the banned substance clenbuterol in two random urine tests. The Nevada Athletic Commission opened an investigation and temporarily suspended Álvarez on March 23, 2018, placing the high-profile bout and his professional reputation in jeopardy. On March 29, commission chief Bob Bennett filed a formal doping complaint, and the disciplinary process was delayed until the commission's April meeting. With the fight's status increasingly uncertain, T-Mobile Arena announced that ticket buyers would be offered full refunds, while Golovkin said he intended to fight on May 5 even if Álvarez was unavailable.
Álvarez officially withdrew on April 3, with Golden Boy Promotions president Eric Gomez saying that Nevada regulations made it impossible for him to be cleared in time. The commission ultimately imposed a six-month suspension, calculated retroactively from February 17, 2018, the date of the first positive sample; the ban therefore expired on August 17. The failed tests forced the postponement of one of boxing's most anticipated rematches and intensified the bitterness between the two camps. Golovkin's side treated the episode as evidence of an unfair competitive advantage, while Álvarez returned to the ring after the suspension and negotiated a new agreement with Golovkin for the rematch, eventually rescheduled for September 15, 2018.
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